Polycystic Ovarian Syndrome (PCOS) is one of the major reproductive and metabolic health issue, and currently recognized as multifactorial, endocrine disorder of less known etiology with an intricate pathophysiology condition with manifestations of hyperinsulinemia and peripheral insulin resistance. The physiological cross talks of PCOS, obesity, metabolic pathophysiology such as type-2 diabetes Mellitus (T2DM) along with CAPN10 genetic polymorphisms, (one of the strong candidate genes for T2DM) conceivably imperative to study in multi-ethnic population like India to facilitate preventive cure. Scanty literature review from Indian context, suggests inconsistent results with regard to the association of CAPN10 gene polymorphism and PCOS, conceivably due to diverse ethnicity in India. In this background the present study attempted to discern the triad association of CAPN10 gene polymorphism (SNP-19), fat patterning with PCOS among the Tibeto-Burman linguistic group of North East India (Tripura). To accomplish the purpose 42 clinically diagnosed PCOs individuals and 94 age matched apparently healthy unrelated non-PCOs participants without familial PCOS were incorporated from autochthonous Tibeto-Burman speakers in the present investigation. Anthropometric variables undertaken to identify fat patterning using standard techniques. Genomic DNA extracted from mouthwash and subsequently, PCR amplification for genotyping of CAPN10 gene polymorphism was executed. Estimated allele and genotype frequencies of the SNPs were evaluated between the cases and controls. Present study discerned a significant (p <0.05) difference of obesity measures among the PCOS and Non-PCOS group indicating increased central obesity among the PCOS in comparison to their Non-PCOS matching part. However, both the allele and genotype frequencies of the CAPN10 (SNP19) gene exhibited no significant association between PCOS and Non-PCOS. Therefore, the present study conclude that, SNP-19 variant of CAPN10 gene might not be a characterized risk factor for PCOS of this population. On the other hand, central adiposity is one of the major risk factors for PCOS.