Despite more than 25 years of liberation from colonial authority, South Africa remains plagued with the repercussions of colonialism. This legacy is still prominent today in various institutions, including but not limited to museums. Although some museums have transformed to create more inclusive and representative histories, most museums are still grappling with the issue of colonialism, especially the lack of an inclusive approach to curation. Can anthropology, a colonial discipline, be utilized to reconfigure museums? is the central question of this paper. Anthropology began as a science of colonialism, the study of languages, cultures, and biology of non-Europeans seen as primitive throughout the world because of settler colonialism. Anthropologists conducted fieldwork anywhere they could find an “indigenous society”. There was an abundance of material culture items that came up in museums because of such incursions into the so called “indigenous” areas. Although there are many anthropologists employed in museum settings, there is a propensity for them to shy away from tackling coloniality in museums, which calls into question the field's applicability in museums. While other scholars argue that it is ludicrous to think that anthropology can be used as a tool to decolonize because it was used to colonize, especially in South Africa, this article challenges the notion that anthropology, having been historically implicated in colonization, cannot serve as a tool for decolonization. The article aims to contribute to ongoing discussions on decolonization within the museum sector and the broader field of anthropology. It further seeks to understand the role of anthropologists in dismantling colonial legacies and promoting indigenous knowledge systems and narratives within museums.