Based on ethnographic fieldwork in a rural setting in Kalahandi region of Odisha, this paper tries to examine the changing agricultural practices and its implications on the larger society. Prior to the introduction of green revolution around two decades before, farming used to be of diverse varieties of rice, grains, pulses, millets which used to be largely organic. Alongwith them, fishes, snails, crabs, prawns used to be part of the normal agricultural practices without much effort which used to be a great support system among the subaltern sections. The agrarian social structure with subsistence economy used to revolve around the nature with worldview shaped by animist and naturalist practices. The region has been witnessing significant changes due to the interventions of the state policies, neoliberal market and the people - both as a response to these two as well as autonomously acting for more than a decade. With the arrival of green revolution by the active intervention of the state in collaboration with the neoliberal market, the local agrarian social structure started changing in a significant way. Green revolution along with its package of knowledge practices and technology started replacing the traditional knowledge system which became redundant. It has a huge implication on the ecosystem leading to the rise in social inequality and climate change. It has started following the path of those areas which have already gone through the same process like in Punjab, Western Uttar Pradesh etc. In this background this paper tries to pose some questions. How can we reimagine the anthropological knowledge to intervene and initiate a dialogue for sustainable development? Are we the practitioners of the disciplines ready to critically examine the dominant narratives and question the status-quo by engaging with the local knowledge system and practices which promises a better alternative to the present?