Queer anthropology is now a relatively well established sub-field within socio-cultural anthropology departments in North America, however, it has been unevenly received by some anthropological communities in the Global South and beyond, with critiques of its Euro-American genealogies and categories, limited cross-cultural translatability, and/or problematic research methodologies. Deploying some of the decolonial critiques of anthropology and queer studies, this paper assesses the potential and limits of queer anthropology as a theoretical framework and research methodology in non-western, Global South locations and/or among social groups with histories of exploitation, marginalization, and invisibilization in settler-colonial societies.