This protocol was developed to allow evaluators to collect up-to-date data and produce a comprehensive annual assessment through several specific indicators and ensure the outcomes that include the most relevant evidence about physical activity/exercise for esports players from each country and recognition of particular barriers for physical activity/exercise. For this reason, this study aims to create a methodology that will provide a better basis for establishing a standardized monitoring system on physical exercise and performance in esports players at national and regional levels as well as globally. This study protocol proposed 20 sociodemographic indicators (country, total population; urban population; human capital index; GDP per capita; GDP growth; unemployment; literacy rate; government expenditure on education; government expenditure on recreational and sporting services; individuals using the internet; mobile cellular subscriptions; fixed broadband subscriptions; high-technology exports; public health expenditure; life expectancy at birth; physical activity prevalence; deaths due to physical inactivity; national physical activity plan; and esports national federation) that are available online and it will be compiled to identify the characteristics of the participating countries and describe country's demographic profile. On the other hand, this protocol proposed nine content indicators (overall physical activity/exercise; formal physical activity/exercise; informal physical activity/exercise; active transportation; sedentary behaviours; physical performance; esports organization; community and environment; and government) that were singled out for the assessment of physical exercise and performance in esports players. To evaluate each of the content indicators, a separate analysis has to be conducted, and a ten-point grading scale will be employed. This study protocol will initiate the national evaluators (researchers) to meet annually to produce national reports (the Country Factsheets) that will ensure effective and dynamic linkages between research and practice.