The COVID-19 pandemic has impacted every segment of our lives. Vaccines as an answer to COVID-19 were appreciated at the earliest moments of the pandemic, but when the potential solution was on the horizon, hesitancy regarding COVID-19 vaccines was prominently evident worldwide. The objectives of this study were: (1) to map out and explore the factors influencing vaccine decision-making with respect to COVID-19 vaccination; and (2) to study vaccine skepticism and meaning-making with reference to the vaccine continuum. A community-based, qualitative study was conducted among individuals aged 18 years and older in the New Delhi region. The sample size was limited 50 participants. The participants belonging to different socio-economic and religious backgrounds were chosen to tap into the diversity. The method of data collection consisted of pile sorting, free listing and in-depth, semi-structured interviews. The audio files of the interviews were transcribed verbatim, followed by a thematic analysis to identify key themes and patterns. The results showcased how there is no single homogeneous frame of the vaccination-continuum but frames of it that are being influenced by personal and shared histories, opinions, wants, and needs. They are embedded within societal networks that have their own unique configuration of world views, which don’t always conform to the perspectives of biomedicine. The relevance of the study lies in highlighting Indian perceptions, concerns, discourses, and particularities and understanding the nexus of culture, society, biology, and health, which can help policymakers develop locally effective vaccine education.