Sleep and wakefulness are most obvious human circadian behaviors, are regulated by circadian rhythms, which play a critical role in health and function. While sleep-wake disorders affect more than 1/3 of the general population. The Center for Sleep and Circadian Medicine of the Affiliated Brain Hospital, Guangzhou Medical University focuses on the in-depth research and clinical application of sleep medicine and biological rhythm. The center uses advanced monitoring technology to provide accurate diagnosis and personalized treatment for patients with various sleep disorders, especially for adolescent patients with sleep disorders and shift workers with circadian rhythm related sleep disorders, and has achieved remarkable clinical applications. In addition, the center has carried out innovative development and clinical application in digital cognitive behavioral therapy for insomnia, realized the combination of standardization and personalized treatment, and greatly improved the treatment effect through real-time data feedback and algorithm adjustment, and was approved as a clinical feature technology in Guangzhou. The center also pays huge attention to teaching and talent training, offering a number of courses such as "Sleep Medicine", and recruiting a number of national and provincial high-level young talents. The academic-discipline team has carried out innovative research work on the deep integration of clinical and basic studies, published more than 20 high-level papers in recent years, and obtained more than 10 state-level scientific research grants. On this basis, this paper discusses the subject construction of medical anthropology.