Human populations have experienced several cumulative revolutions since the beginning of the Holocene, starting with the development of diverse forms of agriculture, moving on to mechanization, industrialization, and urbanization, and concluding with globalization and the digitalization of numerous facets of daily life. Malnutrition has persisted and been unevenly distributed throughout these revolutions, each of which presented new challenges and insults to the ancestral human nutritional niche based on social foraging. Today, human populations face a triple-burden of: 1) overnutrition (overweight and obesity), undernutrition (stunting, wasting and underweight), and micronutrient deficiencies (often referred to as 'hidden hunger'). These burdens often coexist within the same population. Food insecurity in many forms interact with sedentary lifestyles, ‘bad’ diets, and settings that encourage unhealthy behaviour. These problems are often derived from inequalities of the Social-Economic-Political-Emotion (SEPE) infrastructure of communities and nations. While some segments of society struggle to get food, other segments of same society place online orders for meal delivery. Our roundtable will discuss how new forms of personalized nutritional intervention (akin to personalized medicine), along with investments to improve the upstream SEPE infrastructure, may be applied to tackle the triple-burden of malnutrition.