Dengue is the fastest spreading vector-borne disease worldwide, with half of the world’s population at risk of infection. Yet, there is no specific treatment for dengue, vaccines are not widely available, and prevention largely focuses on vector control with toxic substances. Social participation for dengue control has appeared as a promising solution in the last decade. By valuing communities’ sociocultural perspectives and ensuring that initiatives are locally adapted, social participation can contribute to decolonizing control efforts. This roundtable gathers discussants from medical anthropology and global public health to exchange views on the impacts of social participation on dengue control. Discussants will share experiences from Mexico, Nicaragua, Peru, Kenya, Tanzania, and Bangladesh, reflecting work on emerging and re-emerging global health threats in various sociocultural settings and geographies. The roundtable will start by discussing the importance of making dengue a global health priority, considering its pandemic potential. Discussants will present lessons learned from their experiences, ranging from cluster randomized controlled trials testing participatory interventions to prevent dengue in Mexico and Nicaragua, community-based dengue management in the Peruvian Amazon, epidemic management and health education in various African countries, and community-based infectious disease program implementation in Bangladesh. Discussants will highlight the impacts of social participation on dengue control and identify strategies for fostering authentic participation. Featuring multidisciplinary discussants, this discussion provides an opportunity to jointly reflect on the benefits of social participation for dengue control. As the epidemiology of dengue is rapidly changing and no longer confined to urbanized areas in low- and middle-income countries, it is crucial that dengue initiatives are adapted to their contexts in partnership with the communities most affected by the disease. Adopting decolonizing approaches to control dengue could encourage the emergence of innovative strategies and more effective practices. *This roundtable is affiliated to the Commissions on Medical Anthropology and Pandemics.